学术成果
代表性论文：
1. Y. Yang, J. Huang, W. Wei, Q. Zeng, X. Li, D. Xing, B. Zhou*, T. Zhang*, Switching the NIR upconversion of nanoparticles for the orthogonal activation of photoacoustic imaging and phototherapy, Nature Communications, 2022, 13, 3149.
2. J. Zheng, Q. Zeng, R. Zhang, D. Xing*, T. Zhang*, Dynamic-reversible photoacoustic probe for continuous ratiometric sensing and imaging of redox status in vivo. J. Am. Chem. Soc. 2019, 141, 19226-29230.
3. L. Du, H. Qin, T. Ma, T. Zhang*, D. Xing*, In vivo imaging-guided photothermal/photoacoustic synergistic therapy with bioorthogonal metabolic glycoengineering-activated tumor targeting nanoparticles. ACS Nano, 2017, 11, 8930−8943.
4. T. Zhang, R. Lan, C.-F. Chan, G.-L. Law, W.-K. Wong*, K.-L. Wong*, In vivo selective cancer-tracking gadolinium eradicator as new-generation photodynamic therapy agent, PNAS, 2014, 111, E5492-E5497.
5. T. Zhang, X. Zhu, C. C. W. Cheng, W.-M. Kwok, H.-L. Tam, J. Hao, D. W. J. Kwong, W.-K. Wong*, K.-L. Wong*, Water-soluble mitochondria-specific ytterbium complex with impressive NIR emission. J. Am. Chem. Soc., 2011, 133, 20120.
研究论文列表：
41. Q. Zeng, X. Li, J. Li, M. Shi, Y. Yao, L. Guo,* N. Zhi, and T. Zhang*, Totally Caged Type I Pro-Photosensitizer for Oxygen-Independent Synergistic Phototherapy of Hypoxic Tumors, Advanced Science, 2024, 2400462.
40. C. Xie, X. Li, L. Zhang, H.-F. Chau, W. Thor, W. S. Tam, B. Woolley, M. Jiang, C.-F. Ng, M. Botta, T. Zhang*, N. J. Long*, G.-L. Law*, K.-L. Wong*, Bimetallic porphyrin PET radiotracers for Low-Dose MRI contrast enhancement, Chemical Engineering Journal, 2024, 495, 153350.
39. N. Li, X. Li*, J. Li, Y. Li, T. Zhang*, An AND-Gate Photoacoustic Probe for Cys and H2S Precise Photoacoustic Sensing in Localized Tumors, Anal. Chem., 2024, 96, 19, 7342-7347.
38. J. Xu, X. Li,* Z. Luo, J. Li, S. Yang,* T. Zhang*, Single Side-Chain-Modulatory of Hemicyanine for Optimized Fluorescence and Photoacoustic Dual-Modality Imaging of H2S In Vivo, Small Methods 2024, 2400122.
37. S. Xie, X. Li, Q. Zeng, Y. Wu*, T. Zhang*, High-Contrast Photoacoustic Imaging of Localized Cysteine in Orthotopic Breast Cancer Enabled by A Totally-Caged Methylene Blue Probe, Chem. Eur. J. 2024, e202302878.
36. T.-L. Cheung, L. K. B. Tam, W.-S. Tam, L. Zhang, H.-Y. Kai, W. Thor, Y. Wu, P.-L. Lam, Y.-H. Yeung, C. Xie, H.-F. Chau, W.-S. Lo, T. Zhang,* K.-L. Wong*, Facile Peptide Macrocyclization and Multifunctionalization via Cyclen Installation, Small Methods, 2024, 2400006.
35. L. He, Y. Li, Q. Zeng, X. Li, H. Liang, T. Zhang*, A dye-quenched/sensitized switching upconversion nanoprobe for high-contrast mapping of the pH-related tumor microenvironment, Nanoscale, 2023, 15, 16727–16733.
34. C. Xie, Y. Wu, H.-F. Chau, T. Zhang*, C. T. Wong, Y.-H. Yeung, P.-L. Lam, J.-C. G. Bünzli, L. J. Charbonnière,* G.-L. Law,* K.-L. Wong*, Multimodal Visualization of Bioorthogonal Systems
by Off–On Luminescence and Enhanced Magnetic Resonance Imaging, Adv. Optical Mater. 2023, 2203057.
33. Y. Yang, J. Huang, W. Wei, Q. Zeng, X. Li, D. Xing, B. Zhou*, T. Zhang*, Switching the NIR upconversion of nanoparticles for the orthogonal activation of photoacoustic imaging and phototherapy, Nature Communications, 2022, 13, 3149.
32. Q. Zeng, X. Li, S. Xie, D. Xing*, T. Zhang*, Specific disruption of glutathione-defense system with activatable single molecule-assembled nanoprodrug for boosted photodynamic/chemotherapy eradication of drug-resistant tumors, Biomaterials, 2022, 121867.
31. X. Li, Q. Zeng, R. Zhang, J. Li, D. Xing, T. Zhang*, Mitochondria-specific gadolinium (III) porphyrinate as efficient ROS generator for MRI visualization and sonodynamic-immunotherapy of deep localized tumors, Chemical Engineering Journal, 2022, 450, 138210.
30. M. Zhao, Q. Zeng, X. Li, D. Xing*, T. Zhang*, Aza-BODIPY-based phototheranostic nanoagent for tissue oxygen auto-adaptive photodynamic/photothermal complementary therapy, Nano Research, 2022, 15, 716–727.
29. R. Zhang, Q. Zeng, X. Li, D. Xing*, T. Zhang*, Versatile gadolinium(III)-phthalocyaninate photoagent for MR/PA imaging-guided parallel photocavitation and photodynamic oxidation at single-laser irradiation, Biomaterials, 2021, 275, 120993.
28. N. Wang, Q. Zeng, R. Zhang, D. Xing*, T. Zhang*, Eradication of solid tumors by chemodynamic theranostics with H2O2-catalyzed hydroxyl radical burst, Theranostics, 2021, 11, 2334-2348.
27. X. Jin#, Q. Zeng#, J. Zheng, D. Xing*, T. Zhang*, Aptamer-functionalized upconverting nanoformulations for light-switching cancer-specific recognition and in situ photodynamic–chemo sequential theranostics, ACS Appl. Mater. Interfaces, 2021, 13, 9316−9328.
26. Y. Yang, T. Zhang*, D. Xing*, Single 808 nm near-infrared-triggered multifunctional upconverting phototheranostic nanocomposite for imaging-guided high-efficiency treatment of tumors, J. Biophotonics, 2021, 14, e202100134.
25. J.-L. Wang, L. Zhang, M.-J. Zhao, T. Zhang,* Y. Liu, F.-L. Jiang*, Mitochondria-Targeted BODIPY Nanoparticles for Enhanced Photothermal and Photoacoustic Imaging In Vivo, ACS Appl. Bio Mater. 2021, 4, 1760−1770.
24. X. Li, Y. Zhao, J. Zheng, T. Zhang*, Boron dipyrromethene-based near-infrared fluorescent probe for the selective imaging and analyzing hydrogen peroxide in living cells, J. Lumin. 2021, 229, 117642.
23. J. Zheng, Q. Zhan, L. Jiang, D. Xing, T. Zhang*, K.-L. Wong*, A bioorthogonal time-resolved luminogenic probe for metabolic labelling and imaging of glycans. Inorg. Chem. Front., 2020,7, 4062-4069.
22. X. Li, Y. Zhao, T. Zhang*, D. Xing*, Mitochondria-specific agents for photodynamic cancer therapy: A key determinant to boost the efficacy, Adv. Healthcare Mater. 2020, 2001240.
21. R. Zhang, J. Zheng, T. Zhang*, In vivo selective imaging of metabolic glycosylation with a tetrazine-modified upconversion nanoprobe, RSC Advances, 2020, 10, 15990 – 15996.
20. Y. Wu, J. Zheng, Q. Zeng, T. Zhang*, D. Xing*, Light-responsive charge-reversal nanovector for high-efficiency in vivo CRISPR/Cas9 gene editing with controllable location and time. Nano Research, 2020, 13, 2399–2406.
19. Y. Wu, J. Zheng, D. Xing*, T. Zhang*, Near-infrared light controlled fluorogenic labeling of glycoengineered sialic acids in vivo with upconverting photoclick nanoprobe. Nanoscale, 2020, 10361-10368.
18. J. Zheng, Q. Zeng, R. Zhang, D. Xing*, T. Zhang*, Dynamic-reversible photoacoustic probe for continuous ratiometric sensing and imaging of redox status in vivo. J. Am. Chem. Soc. 2019, 141, 19226-29230.
17. J. Zheng, Y. Wu, D. Xing*, T. Zhang*, Synchronous detection of glutathione/hydrogen peroxide for monitoring redox status in vivo with a ratiometric upconverting nanoprobe. Nano Research, 2019, 12, 931-938.
16. Q. Zeng, R. Zhang, T. Zhang*, D. Xing*, H2O2-responsive biodegradable nanomedicine for cancer-selective dualmodal imaging guided precise photodynamic therapy, Biomaterials, 2019, 207, 39-48.
15. Y. Wu, G. Guo, J. Zheng, D. Xing*, T. Zhang*, Fluorogenic “photoclick” labeling and imaging of DNA with coumarin-fused tetrazole in vivo. ACS Sensors, 2019, 4, 44−51.
14. W. Fang, Y. Wei, Y. Ye, T. Zhang*, D. Xing*, Oxyhemoglobin-monitoring photodynamic theranostics with an 808 nmexcited upconversion optical nanoagent. Chemical Engineering J., 2018, 350, 108-119.
13. T. Ma, J. Zheng, T. Zhang*, D. Xing*, Ratiometric photoacoustic nanoprobes for monitoring and imaging of hydrogen sulfide in vivo. Nanoscale, 2018, 10, 13462-13470.
12. L. Du, H. Qin, T. Ma, T. Zhang*, D. Xing*, In vivo imaging-guided photothermal/photoacoustic synergistic therapy with bioorthogonal metabolic glycoengineering-activated tumor targeting nanoparticles. ACS Nano, 2017, 11, 8930−8943.
11. Q. Ding, Q. Zhan, X. Zhou, T. Zhang*, D. Xing*, Theranostic upconversion nanobeacons for tumor mRNA ratiometric fluorescence detection and imaging-monitored drug delivery. Small, 2016, 12, 5944.（Front Cover）
10. T. Zhang, R. Lan, L. Gong, B. Wu, Y. Wang, D. W. J. Kwong, W.-K. Wong, K.-L. Wong,* D. Xing*, An amphiphilic BODIPY-porphyrin conjugate: intense two-photon absorption and rapid cellular uptake for two-photon-induced imaging and photodynamic therapy, ChemBioChem, 2015, 16, 2357 – 2364. (Back Cover)
9. D. Qi, Q. Wang, H. Li, T. Zhang, R. Lan,* D. W. J. Kwong, W.-K. Wong, K.-L. Wong,* S. Li*, F. Lu*, SILAC-based quantitative proteomics identified lysosome as a fast response target to PDT agent Gd-N induced oxidative stress in human ovarian cancer IGROV1 cells, Mol. BioSyst., 2015, 11, 3059--3067
8. T. Zhang, R. Lan, C.-F. Chan, G.-L. Law, W.-K. Wong*, K.-L. Wong*, In vivo selective cancer-tracking gadolinium eradicator as new-generation photodynamic therapy agent, PNAS, 2014, 111, E5492-E5497.
7. T. Zhang, C.-F. Chan, R. Lan, W.-K. Wong, K.-L. Wong, Highly selective and responsive visible to near-IR ytterbium emissive probe for monitoring mercury(II), Chem. Eur. J. 2014, 20, 970 – 973
6. T. Zhang, C.-F. Chan, R. Lan, P.-S. Chan, N.-K. Mak, W.-K. Wong*, K.-L. Wong*, Selective differentiation of cancer cells by porphyrin-based ytterbium complexes targeting anionic phospholipid membrane. Chem. Commun., 2013, 49, 7252-7254.
5. T. Zhang, X. Zhu, W.-K. Wong*, H.-L. Tam, W.-Y. Wong*, Light-harvesting ytterbium (III)-porphyrinate-BODIPY conjugates: synthesis, excitation-Energy transfer, and two-photon-induced near-infrared-emission studies. Chem. Eur. J., 2013, 19, 739-748.
4. T. Zhang, C.-F. Chan, J. Hao, G.-L. Law, W.-K. Wong*, K.-L. Wong*, Fast uptake, water-soluble, mitochondria-specific erbium complex for a dual function molecular probe – imaging and photodynamic therapy. RSC Advances, 2013, 3, 382-385.
3. T. Zhang, X. Zhu, C. C. W. Cheng, W.-M. Kwok, H.-L. Tam, J. Hao, D. W. J. Kwong, W.-K. Wong*, K.-L. Wong*, Water-soluble mitochondria-specific ytterbium complex with impressive NIR emission. J. Am. Chem. Soc., 2011, 133, 20120.
2. H. Ke,* W. Li, T. Zhang, X. Zhu,* H.-L. Tam, A. Hou, D. W. J. Kwong*, W.-K. Wong*, Acetylene bridged porphyrin–monophthalocyaninato ytterbium(III) hybrids with strong two-photon absorption and high singlet oxygen quantum yield, Dalton Trans., 2012, 41, 4536–4543
1. X.-J. Zhu,* T. Zhang, S. Zhao, W.-K. Wong,* W.-Y. Wong, Synthesis, Structure, and Photophysical Properties of Some Gadolinium(III) Porphyrinate Complexes, Eur. J. Inorg. Chem. 2011, 3314–3320
